EVALUACIÓN DEL FRAX ECUADOR COMO PREDICTOR DE OSTEOPOROSIS EN PACIENTES DE UN CENTRO DE REUMATOLOGÍA DE GUAYAQUIL. PERÍODO SEPTIEMBRE 2016 A MARZO 2017.

Abstract

Introduction: Osteoporosis screening with bone mineral density measurement is not adequate because of its poor benefit-cost relationship reflected on its low sensitivity. This motivated the development of FRAX, an algorithm that allows to calculate 10 year risk of hip fracture and any other osteoporotic fracture, based on independent clinical risk factors. Studies show that a FRAX value that demonstrates elevated risk approaches the diagnosis of osteoporosis and justifies the study of bone mineral density. Objective: To analyze FRAX Ecuador as an osteoporosis predictor. Methods: A cross-sectional study was conducted, in which patients of a rheumatology center who underwent a bone mineral density study during September 2016 to March 2017 were included. FRAX calculator was applied to the population and its results were compared to the ones of the bone mineral density measurements. Risk assessment was based on international osteoporosis guides’ criteria. Results: FRAX mean for major osteoporotic fracture was 2,2 and for hip fracture 0,9. Significant statistic association was found between higher values of FRAX and osteoporosis. The international thresholds had low sensitivity for its use in the population. The threshold of FRAX0,8 rose sensitivity up to 85%. xi Conclusion: FRAX Ecuador is useful for the prediction of osteoporosis, as long as population-adjusted intervention thresholds are used, improving diagnosis approaches and avoiding unnecessary complementary studies