CORRELACIÓN DEL GRADO DE COMPATIBILIDAD HLA CON LA ENFERMEDAD INJERTO CONTRA HUÉSPED EN ALOTRASPLANTE DE CÉLULAS HEMATOPOYÉTICAS EN SOLCA EN LA ÚLTIMA DÉCADA

Abstract

Allogeneic hematopoietic stem cell transplantation (AHSCT) has been used primarily as a curative treatment for hematological and nonhaematological malignancies. The objective of the study is to determine the relation between the degrees of HLA compatibility of hematopoietic cell transplant recipient and graft versus host disease in SOLCA in the last decade. It is an observational, retrospective and cross-sectional study in patients submitted to allogeneic haematopoietic stem cell transplantation during the period January-2006 to December-2016; who also had immunological and molecular evidence of HLA compatibility. A datasheet containing the variables: age, sex, primary diagnosis, type of transplantation, HLA compatibility index, presence of graft versus host disease, form and clinical manifestations were applied. The obtained data will be stored in an Excel database and will be analyzed with the SPSS statistical software applying relationship methods for the fulfillment of the proposed objectives. The results were the following: 17.39% of the patients included in this study developed GVHD; despite having 100% HLA compatibility. 75% corresponded to the masculine gender, appearing more frequently in children under 35 years; with a diagnosis of acute lymphocytic leukemia (21.4%). The most common form of presentation was manifested with mucocutaneous, digestive and hepatic symptoms. A high prevalence of the disease was identified. It was observed that those patients underwent an allogeneic type transplant, and presented 100% HLA compatibility between the selected donor and the recipient.