Nivel de adherencia al tratamiento con Warfarina en pacientes con enfermedad cardiovascular establecida de Guayaquil, Ecuador

Abstract

Warfarin is a commonly used drug in Ecuador for the treatment of various cardiovascular conditions, mainly atrial fibrillation and valvular pathologies. However, there are no studies on the level of pharmacological adherence and the factors associated with different levels of adherence to this drug. Our study aimed to determine the level of pharmacological adherence to warfarin in patients with cardiovascular disease using the Morisky-Green 4 questionnaire, in addition to collecting sociodemographic and clinical data to identify associations at different levels of adherence. A total of 102 patients were included in the analysis, and from this sample it was estimated that our population had a moderate level of adherence (p<0.001). It was determined that factors associated with high levels of adherence were being married (p<0.05) and having employment (p<0.014), while low adherence was associated with economic problems (p<0.000), forgetting to take the medication (p<0.000), being single or widowed (p<0.05), being male (p<0.016) and being unemployed (p<0.014). The latest International Normalized Ratio reading was not significatively associated with the level of adherence (p=0.356).